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KMID : 1025520050470020159
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Journal of Animal Science and Technology
2005 Volume.47 No. 2 p.159 ~ p.166
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Association Between MSTN Gene Polymorphism and Growth Traits in Landrace Pigs
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Cho In-Cheol
Choi Y. L.
Ko Moon-Suck
Kim H. S.
Lee Jung-Gyu
Jeon Jin-Tae
Han Sang-Hyun
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Abstract
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Porcine myostatin(MSTN) gene plays a key role in the differentiation of myoblast and muscle development. Genetic polymorphism was screened by single stranded conformation polymorphism(SSCP) analysis and subsequent DNA sequencing detected a nucleotide substitution(C2150T) in exon 3 of MSTN gene. Phenotypic association of the polymorphism was tested in a Landrace population and positive effects of the allele T for lean growth traits were found in the population. Even though it is not significant, the pigs have TT and TC genotypes were heavier for the body weight at birth and at twenty weeks of age than those containing genotype CC. However, the allele T was significantly associated with higher eye muscle area(P<0.05). As a result of this study, we suggested that the allele T in exon 3 of MSTN gene comes a significant effect for increasing the eye muscle area without decreasing backfat thickness. This polymorphism did not change the amino acid but TaqⅠ-RFLP matched to SSCP band patterns in exon 3 of MSTN gene, which will be an useful molecular marker for breeding of Landrace pigs.
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KEYWORD
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Association, Genotype, Growth trait, Myostatin, SSCP
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